Understanding the role of TGFbeta signaling in cancer

Chair: Gareth Inman, University of Dundee, UK
Speaker: Joan Seoane, Val D’Hebron Institute of Oncology, Spain
Speaker: Caroline Hill, The Francis Crick Institute, UK
Speaker: Carl-Henrik Heldin, The Ludwig Institute for Cancer Research, UK


Room: M1

TGFb is a pleitropic cytokine that can have profound effects on the development, progression and metastatic spread of tumours acting as a potent tumour suppressor or powerful tumour promoter in a context dependent manner. Understanding, how, where and when TGFb signalling influences these processes is the focus of this session. The regulation and control of TGFb signalling pathway dynamics, the molecular mechanisms underpinning TGFb driven tumour control and the potential of targeting TGFb signalling for tumour therapy will be discussed. This session should appeal to basic scientists, clinical academics, oncologists and the pharmaceutical industry.