Tumour cell plasticity as a challenge for targeted therapies

9:45 am-10:25 am

Room: Lomond Auditorium

Programme stream(s): Treatment
Programme session type(s): Plenary session

Chair: Eric O’Neill, University of Oxford
Speaker: Frederic de Sauvage, Genentech Inc

The Wnt and Hedgehog signalling pathways play critical roles during embryonic development and in adults through modulation of proliferation, cell migration and differentiation. Inappropriate activation of these pathways through mutations in a resident stem cell can result in tumorigenesis, in particular in the gastrointestinal tract and in the skin. Targeting these oncogenic pathways or the stem cells compartment driving the tumorigenic process represent therapeutic opportunities for the treatment of these tumour types. However, we also uncovered that plasticity between cell compartments involved in tissue repair and regeneration processed poses new challenges for the efficacy of these therapeutic approaches in cancer.