SWI/SNF in cancer

Host: Jessica Downs, Institute of Cancer Research, UK


Room: Room 2N

Genes encoding subunits of the SWI/SNF chromatin remodelling complex are inactivated with striking frequency in human cancer. Current estimates indicate that roughly 1 in 5 cancers have a mutation in one of the SWI/SNF subunits. Understanding what this complex does and how it normally prevents tumourigenesis is of great importance.

In this session, leaders in the field will provide insights into the structure and mechanism of the complex, and how SWI/SNF remodelling activity impacts on global chromatin organization. They will share their latest results investigating the cellular functions of SWI/SNF and how these are relevant to cancer biology and treatment.

Confirmed speakers:
Tom Owen-Hughes, University of Dundee, UK
Cigall Kadoch, Dana-Farber Cancer Institute and Harvard Medical School, USA
Christian Muchardt, Institut Pasteur, France

Variation in the protein composition of SWI/SNF chromatin remodelling complexes in clear cell renal carcinoma