Modelling the biology of glioblastoma

Chair: Simona Parrinello, University College London, UK
Speaker: Anthony Chalmers, University of Glasgow, UK
Speaker: Steve Pollard, University of Edinburgh, UK
Speaker: Peter Dirks, Sick Kids, Canada


Room: Boisdale

Glioblastoma (GBM) is the most common and malignant type of brain tumour, characterized by high recurrence and short survival. The pervasive cellular and molecular heterogeneity of GBM and insufficient understanding of its biology remain key clinical challenges. Preclinical models that accurately recapitulate GBM complexity are therefore essential for increasing understanding of disease mechanisms and developing improved therapies. This session will focus on recent advances in GBM modelling and on how these models are providing key insights into disease biology and innovative treatment strategies. Topics covered will include genomic drivers, mechanisms of cancer stem cell quiescence, self-renewal and maintenance, and invasion.