Mechanotransduction and invasion: The tumour microenvironment perspective

Programme stream(s): Cancer discovery / underpinning research

Chair and speaker: Erik Sahai, The Francis Crick Institute
Speaker: Danijela Vignjevic, Curie Institute, Paris
Speaker: Fran Balkwill, Queen Mary University of London

2:00 pm-3:30 pm

Room: Boisdale

This session will focus on recent advances in our understanding of the mechanical environment of tumours and how it is both determined by and modulates the function of cells in the tumour microenvironment. In particular, the mechanical properties of the extracellular matrix can act as either a barrier to cancer invasion or form permissive tracks. These same structures can also modulate the migration and distribution of tumour infiltrating leukocytes, with possible consequences for immunotherapies. The session will largely be targeted at researchers, but will provide a sufficiently generic introduction that will engage clinicians and informed lay people.