DNA damage repair

Host: Chris Lord, The Institute of Cancer Research


Room: Room 3A

Tumour-specific defects in the DNA damage response network (DDR) not only drive the development of cancer but also present opportunities for therapeutic intervention. In this symposium, we will discuss recent developments in the basic understanding of the DDR, efforts to target the DDR as a therapeutic approach and emerging mechanisms of resistance to DDR inhibitors.

Confirmed speakers:
Alan D’Andrea, Center for DNA Damage and Repair (CDDR), Harvard Medical School and Dana-Farber Cancer Institute, USA
Judith Balmaña, Head of the High Risk and Cancer Prevention Group, VHIO, Barcelona, Spain
Laurence Pearl, University of Sussex, UK

PARP inhibitor resistance and acquired vulnerability in ovarian cancer
Phosphorylation-dependent assembly of DNA damage response complexes