Plenary lecture: Cancer Research UK Lifetime Achievement award – Progress in therapeutic cancer prevention – Professor Jack Cuzick, Queen Mary University of London, UK

17:40-18:20

Room: Hall 1A

Sponsored by:
Cancer Research UK

Professor Jack Cuzick has received the Cancer Research UK Lifetime Achievement Award for his work on cancer prevention and detection. This prestigious prize is awarded annually to an outstanding researcher who has demonstrated a lifetime commitment to the fight against cancer and has made exceptional advances in the field. The award will be presented at the Conference and will celebrate an exceptional career that’s spanned more than 30 years.

Overview
Breast cancer has been my major area of involvement for therapeutic cancer prevention, dating to 1985 when we found that tamoxifen not only prevented recurrence but also new tumours in the contralateral breast. That led to four major prevention trials including our own IBIS 1 trial for which we continue to see about a 30% incidence reduction for 20 years. For post menopausal women the aromatase inhibitors look to be a better choice with greater efficacy and fewer side effects based on IBIS 2. Work on these studies has led to improved risk assessment and the discovery that reduction in breast density predicts response to endocrine treatment. More recently low dose aspirin emerges as the second most important way of preventing cancer, exceeded only by avoiding tobacco. These subjects will be reviewed from a personal perspective with reflections on my journey through the field of cancer prevention.