Malcolm Brenner

Baylor College of Medicine (BCM), Texas Children’s Hospital and The Methodist Hospital, Houston, USA

Dr Malcolm Brenner, MD, PhD, is Founding Director of the Center for Cell and Gene Therapy at Baylor College of Medicine (BCM), Texas Children’s Hospital and The Methodist Hospital. He serves as a professor in the Departments of Pediatrics and of Medicine at BCM. Brenner received his medical degree and subsequent PhD from Cambridge University, England. Brenner’s clinical research interests span many aspects of stem cell transplantation, using genetic manipulation of cultured cells to obtain therapeutic effects. Efforts in Brenner’s laboratory to analyse the cell of origin when relapse occurs in patients with acute myelogenous leukaemia led Brenner’s team to be the first to label autologous bone marrow cells genetically after purging, prior to being reintroduced to the patient. He is studying the effects of gene transfer into autologous neuroblastoma cells and the use of gene-modified EBV-specific cytotoxic T lymphocyctes for prevention and treatment of lymphoproliferative disorders, Hodgkin’s disease, lung cancer and neuroblastoma. His group recently pioneered the first clinical use of a new safety switch for cellular therapy. Brenner is Editor in Chief of ‘Molecular Therapy’ and a former President of the American Society for Gene and Cell Therapy (ASGCT) and the International Society for Cell Therapy. He has won many awards for his work and in 2011 these included the ASGCT Outstanding Achievement Award and the American Society of Hematology Mentor Award.