Poster session B


Room: Hall 2

FIT sample stability for haemoglobin-positive faeces using three analytical systems over seven days
Change in tobacco and alcohol consumption following a diagnosis of head and neck cancer: results from Head and Neck 5000
Smoking and alcohol consumption as predictors of outcome in head and neck cancer: results from the Head and Neck 5000 study.
A preliminary study to compare cfDNA levels in lung cancer cases and high risk controls to evaluate the role of cfDNA levels in early lung cancer detection
Pre-natal medical radiation exposure in pediatric blood cancers: single institution study, 1990-2015
A comparison of the yield from endoscopic surveillance in detecting early gastric cancer in CDH1+ve versus CDH1-ve HDGC families
Socioeconomic Deprivation and the Burden of Head and Neck Cancer- Regional variations of Incidence and Mortality in Merseyside and Cheshire, North West, England.
Using text mining to automatically extract radiation esophagitis from free-text clinical narratives for clinical decision support
Clinical features and Histological subtypes of RCC. Single center experience
Incidence and progression of Barrett’s oesophagus in clinical practice: A cohort analysis for planning of the Barrett’s ESophagus Trial 3 (BEST3) comparing the Cytosponge-TFF3 test with usual care
Metabolism biomarkers measured before prostate cancer diagnosis and second primary tumours: a prospective study in the Swedish AMORIS cohort.
Survival prognosis following diagnosis of metastatic renal cell carcinoma: is performance status alone a sufficient predictor?
The GASTROS Study: Standardising Outcome Reporting in Gastric Cancer Surgery Research
Concomitant use of antiacids in patients with advanced hepatocellular carcinoma (HCC) receiving sorafenib therapy
The Management of Ductal Carcinoma In-Situ at Charing Cross Hospital
Characterisation of the Arachidonic Acid Metabolising Pathway in Colorectal Cancer
The Effectiveness and Challenges of Data Oriented Patient Assessment: A Case Study in Head and Neck Cancer
Adjuvant radiotherapy after therapeutic lymph node dissection in high-risk Stage III melanoma: the Cambridge experience
Molecular profiling of signet ring cell colorectal cancer provides a strong rationale for genomic targeted and immune checkpoint inhibitor therapies
Post chemotherapy hydration and acute kidney injury in patients undergoing concurrent cisplatin chemoradiotherapy (CRT) for head and neck cancers
A comprehensive analysis of immunotherapy trials reveals a paucity of translational research endpoints in trial design
The HeartSpare Plus 1A Trial: A dosimetric comparison of breast radiotherapy techniques to treat locoregional lymph nodes including the internal mammary chain (IMC)
Quality Indicators for Sentinel Lymph Node Biopsy in Breast Cancer: Applicability and Clinical Relevance
Neoadjuvant Chemoradiotherapy in Resectable Oesophageal Cancer Patients: UK Practice
Preliminary activity in the first in human study of the first-in-class fatty acid synthase (fasn) inhibitor, tvb-2640
FOCUS4-D: Results of a randomised, placebo controlled trial of AZD8931 (HER1, 2, 3 inhibitor) in advanced/metastatic colorectal cancer tumours that are wildtype for BRAF, PIK3CA, KRAS & NRAS
Discovery of G protein-coupled receptor 158 as a potential glioma biomarker
TARDOX: Early Results of a Phase I Study of Targeted Delivery of Lyso-Thermosensitive Liposomal Doxorubicin (ThermoDox®) By Focused-Ultrasound Hyperthermia for Liver Tumours
Medicinal Plants from Oman Inhibit Growth of Ovarian and Breast Cancer Cells
The correlation between quantitative parameters in mutiparametric MRI and PI-RADS 2.0.
Is there a role for prophylactic G-CSF in breast cancer patients receiving docetaxel chemotherapy in combination with carboplatin or cyclophosphamide?
Accuracy of FDG-PET-CT response assessment following (chemo)radiotherapy for locally advanced larynx and hypopharyngeal carcinoma
Between and within patient imaging heterogeneity highlights differences between Vemurafenib, Dabrafenib and Trametinib in metastatic melanoma
OPTIMA: a prospective randomised trial to validate the predictive utility and cost-effectiveness of gene expression test-directed chemotherapy decisions
FAKTION; Phase 1b/2 randomised placebo controlled trial of fulvestrant +/- AZD5363 in postmenopausal women with advanced breast cancer previously treated with a 3rd generation aromatase inhibibitor
TARDOX: Safety and Feasibility of Targeted Delivery of Lyso-Thermosensitive Liposomal Doxorubicin (ThermoDox®) By Focused-Ultrasound Hyperthermia for Liver Tumours
Identification and characterisation of cyclic peptide inhibitors of Ras/PI3K and Ras/Raf protein complexes
What factors influence the patient and primary care intervals in the diagnostic pathway of gynaecological cancers?
Mammaglobin-A tissue expression and 5-year survival in breast cancer
Capecitabine and streptozocin ± cisplatin for gastroenteropancreatic neuroendocrine tumours: predictors of long-term survival in the NET01 trial
High-throughput miRNA-inhibitors screening identified selected miRNAs involved in the modulation of FOLFIRINOX chemotherapy in pancreatic cancer
Assessing the stability of clinically relevant prognostic, predictive and subtyping gene expression signatures based on intra-tumoural heterogeneity in colorectal cancer
Evaluation of Average Intensity Projection (AvIP) in outlining a planning target volume for oesophageal cancer patients
Lancashire and South Cumbria Cancer Network (LSCCN) experience of nab-paclitaxel (Abraxane) and gemcitabine in the treatment of metastatic pancreatic cancer
Use of haematological and biochemical parameters to identify paraproteinaemia patients in need of further investigations to rule out myeloma
Selectively targeting TSC1/2 deficient cells by exploiting endoplasmic reticulum stress and oxidative stress
Short-course radiotherapy followed by neo-adjuvant chemotherapy in rectal cancer with synchronous liver metastases: a single institution experience.
Is there a role for palliative pelvic radiotherapy in pelvic symptom control in metastatic/unresectable rectal cancer?
Early outcomes in stereotactic body radiotherapy (SBRT) for metastatic breast cancer: an analysis of toxicity and local control.
Cytotoxic pimarane diterpenes from Juniperus servaschanica
What is the most commonly prescribed treatment for metastatic endometrial cancer in the second line setting in the UK, and how effective is this treatment?
Clinical and therapeutic significance of Folate receptor alpha (FRα) in ovarian cancer
A regional audit on the management of ALK positive non-small cell lung cancer patients with crizotinib in the East of England
In vitro anticancer properties and biological evaluation of novel natural alkaloid jerantinine B
Detection of Circulating Tumour Cells for use as Prognostic, Predictive and Pharmacodynamic biomarkers in Neuroblastoma
Conformity analysis of target-volume definition for margin-directed boost in pancreatic cancer SBRT
Comparison of three different tumour budding methods to evaluate the prediction of lymph node metastasis in pT1 colorectal carcinomas
Investigating the impact of busulfan and melphalan exposure on toxicity in high-risk neuroblastoma patients – results from the European HR-NBL1/SIOPEN trial
Application of Next Generation Sequencing in Liquid Biopsy analysis
Service Review of Liposomal Doxorubicin in Gynaecological Cancers
MErCuRIC1: A Phase Ia study of MEK1/2 inhibitor PD-0325901 with cMET inhibitor crizotinib in patients with advanced solid tumours
Sensitizing p53 mutant HNSCC to oncolytic reovirus (RT3D) by targeting the ER stress response
SPORT High-Risk Trial: A Randomised Feasibility Study Evaluating Stereotactic PrOstate RadioTherapy in High-Risk Localised Prostate Cancer with or without Elective Nodal Irradiation
Coxsackievirus A21- A potential novel immunotherapy for bladder cancer
Current UK practice in palliative treatment of muscle invasive bladder cancer (MIBC) and impact on design of the phase III HYBRID adaptive image guided radiotherapy (IGRT) trial
Nivolumab in patients with advanced NSCLC and central nervous system (CNS) metastases
Efficacy of Carboplatin in oesophago-gastric cancer:The West Suffolk experience
Transient Surge in Carinoembryonic Antigen Levels During Adjuvant Chemotherapy for Colorectal Cancer is Not Associated with Relapse
To evaluate the accuracy of preoperative standard MRI scan in local staging of prostate cancer.
Surgical Outcome of Gastrointestinal Lymphoma: Experience from a Tertiary Care Center of North India
Cervical Cancer Screening in HIV Positive Women
Preclinical investigations of the potential of PARP and ATR inhibitors in ovarian cancer
Evaluation of sentinel lymph node metastatic deposit size and extracapsular spread on further axillary spread in breast cancer patients.
Randomised trial to investigate two different schedules of nab-paclitaxel combined with gemcitabine as first line treatment for pancreatic cancer: delivering end-points of the SIEGE trial protocol
How reliable is data collected in clinical trials? Experience of safety monitoring in the SIEGE pancreatic cancer clinical trial
The changing face of metastatic breast cancer: A Sussex perspective
Optimisation of the PIG-A test: a diagnostic predictor of oesophageal adenocarcinoma development.
Three dose-level prostate SBRT: a feasibility study
4 years’ experience with HDR prostate brachytherapy boost- toxicity and biochemical control
Molecular characterization of PD-L1 status on circulating tumour cells (CTCs) isolated from patients with advanced cancers
A comparison of 4DCT-derived and 4D-PET-CT-derived planning target volumes for oesophageal cancer patients
Clinical decision making in patients with Metastatic Breast Cancer in the United Kingdom (UK) and Italy
Accelerating Phase I oncology trials, knowing when to apply the safety brakes: the experience of CR UK Centre for Drug Development (CDD) Study management.
Associations between oncogenic mutations: A possible underlying cause of heterogeneous responses to chemotherapy in patients with advanced colorectal cancer.
POLE proofreading domain mutation defines a subset of immunogenic colorectal cancers with excellent prognosis
Evaluation of immune checkpoint marker co-expression profiles in the tumor microenvironment
Designing a practice-changing trial for a rare cancer population: The Rational MCC trial of first definitive treatment for Merkel cell carcinoma
5-aminolevulinic acid-mediated fluorescence diagnosis of colon cancer: a histopathological comparison of fluorescent and non-fluorescent tumours
Research Database of Sequential Mammography Screening events: a source of big data to investigate changes to routine screening
Two-year overall survival rates from a randomized phase 2 trial evaluating the combination of nivolumab and ipilimumab versus ipilimumab in patients with advanced melanoma
The ADRRAD Trial: Neo-adjuvant Androgen Deprivation Therapy, Pelvic Radiotherapy and Radium-223 for new presentation T1-4 N0-1 M1b adenocarcinoma of prostate
Differential sensitivities to cisplatin and rucaparib alone and in combination in cervical cancer cell lines
What are the factors influencing General Practitioners in the use of electronic clinical decision support systems? A review paper to support the scaling of the Macmillan Cancer Decision Support Tool.
Stereotactic Ablative Radiation Therapy (SABR) for High-Risk Prostate Cancer using Volumetric Modulated Arc Therapy (VMAT)
Evaluating the potential of kinase inhibitors to suppress DNA repair and sensitise ovarian cancer cells to PARP inhibitors
Therapeutic Relevance of the 3q26-29 Amplicon in Oral Squamous Cell Carcinoma
Effect of Laxatives in reducing number of Radiotherapy Planning CT scans attempts in patients receiving treatment for Prostate Cancer
Palliative thoracic radiotherapy for NSCLC: a single centre audit of outcomes
Over-age Self referrrals in the English Bowel Cancer Screening Programme – are they the worried well or the symptomatic needing something more?
Ruthenium-based intercalators and targeted radionuclide therapy for oesophageal cancer
A systematic review of MRI-only radiotherapy treatment planning techniques
A higher integral heart dose is associated with lymphocytopaenia in non-small cell lung cancer patients treated with intensity modulated radiotherapy and concurrent chemotherapy.
Formin-like protein 1: a new drug target in breast cancer
SPARC: A Phase I trial of pre-operative, margin intensive, stereotactic body radiation therapy (SBRT) for previously untreated borderline resectable pancreatic cancer
Additional normal tissue sparing with daily plan re-optimisation compared to ‘plan of the day’ image guided adaptive radiotherapy (IGART) in the hypofractionated treatment of bladder cancer
Volumetric Intensity Modulated Arc Therapy vs IMRT in head and neck cancer: comparison of doses to planning target volumes and organs at risk in patients treated at the Gloucestershire Oncology Centre
Immunological characterisation of Giant cell tumour of the bone: The role of B7-H3
Chondrosarcoma and Immunotherapy: Potential role of B7-H3 in the clinical course of the disease in chondrosarcoma
The REQUITE-AB study: Validating predictive models and biomarkers of radiotherapy toxicity to reduce side-effects and improve quality of life in breast cancer patients
Optimisation of irradiation schedules on head and neck cancer cell lines for transfer into a bespoke on-chip system bearing tumour biopsies.
Molecular analysis of ATMIN function
SAHA-induced TRAIL-sensitisation is enhanced in 3D cell culture
Investigating the p53 dependency of synergy of HDAC inhibition with chemotherapy in Colorectal Cancer
A comparison of the prognostic value of the adaptive, T-lymphocyte and generalised inflammatory infiltrate in patients with primary operable colorectal cancer
The influence of soluble factors from the head and neck squamous cell carcinoma tumour microenvironment on regulatory T cell induction and PBMC viability
Effect of melatonin treatment on the intratumor heterogeneity in breast cancer model
Capture of circulating tumour cells with epithelial and mesenchymal features for prostate cancer prognosis
Synthetic lethal targeting of ATR-Chk1 pathway in PTEN-deficient breast cancers for personalisation of therapy
Translational reprogramming in lung adenocarcinoma is central to disease phenotype plasticity
A genome-wide RNAi screen identifies G2 catenation checkpoint players not shared with other G2 checkpoints
Prediction of survival in real world patients with metastatic castrate-resistant prostate cancer, receiving first line Docetaxel chemotherapy- a comparison with the current prediction model
Inhibition of p38 MAPK in myeloid dendritic cells enhances their T cell activation and increases the effects of checkpoint blockade
High Expression of Rsf-1 Correlates With Poor Prognosis in Breast Cancer
Recruitment of myeloid cells to colorectal cancer liver metastasis
The role of oncogenic RAC1 in melanoma initiation and progression
Inhibition of mitochondrial metabolism by dimethyl-oxalylglycine associated with cell death
Development of ex vivo platform of tumour explants to predict clinical response to novel anticancer drugs
Copy Number Aberration-induced Gene Breakage Analysis Identifies Recurrent FOXP1 Fusions in Breast Cancer
Complications of Haematological malignancy: a possible chemotherapy-induced Bystander effect
A novel oncogene-selective sensitivity to synchronous ferroptotic cell death following nutrient modulation
Investigation of anticancer mechanisms of disulfiram and its analogues in lung cancer cell lines
Regulation of Myofibroblast Differentiation within the Tumour Microenvironment: the Role of the DNA Damage Response Pathway
Stepwise progression lung adenocarcinoma - correlating histological changes and molecular events
Nutlin and Oxaliplatin induce p53-dependent addiction to FLIP
Angiopoietin-like 2 (ANGPTL2) expression by human myxofibrosarcoma tumour cells does not affect their proliferation and invasion on collagen I matrix in 2D and 3D in vitro models.
Nano-encapsulated Disulfiram suppresses the progression of glioblastoma in vivo by reversing hypoxia induced invasive stem-like features and chemoresistance
Developing and implementing a community-based prostate cancer awareness and early detection campaign for hard to reach men
We Are Here! Making the NHS and our SaTH Patients Better
A Protocol for a Systematic Evaluation of Patient-Reported Outcome (PRO) Protocol Content and Reporting in UK Cancer Clinical Trials: the EPiC study.
What is it about cancer that worries people? A population-based survey of adults in England
Faking it: Building a Simulacrum of non-identifiable modelled cancer data to support research
Holistic concerns – A patient perspective analysis of electronic Holistic Needs Assessments
What motivates people with cancer to get active?
Recruitment aids for a phase II randomised trial in low risk bladder cancer
A Carer's Perceptions of Patient and Public Involvement in Research
We’ve Got It Covered… Mapping the Activities of Members of the NCRI Consumer Forum Across the INVOLVE Research Cycle
Why Involve 'Consumers' in Cancer Research?
Using acupuncture to treat hot flashes and night sweating for patients with breast cancer
How common is fraility in the radiotherapy department outpatient population?
End of Life Care for Cancer Patients on a Surgical Ward.
The Long-Term And Late Effects Of The Diagnosis And Treatment Of Colorectal Cancer
Rate of cachexia in lung cancer
“You are not alone” – process evaluation of a residential conference for young people with cancer
Enhanced Supportive Care in Experimental Cancer Medicine Trials at The Christie NHS Foundation Trust
The Extent and Impact of Musculoskeletal Dysfunction on Women following Breast Reconstruction using the Latissimus Dorsi Muscle: A Questionnaire Survey
Sarcopenia in lung cancer
The meaning of the tem 'breast cancer survivor' for young women living with a history of breast cancer in the UK
Social support up to 2 years after treatment for colorectal cancer: results from the UK Colorectal Wellbeing (CREW) cohort study
How many people are living with cancer in the UK at the end of 2013?
Research to support the development of a national metric for Quality of Life
Beyond Life & Death – Measuring recurrence, progression and functional outcomes in patients with cancer
Launch of the national breast screening after radiotherapy dataset (BARD) – an initiative to improve breast cancer screening in lymphoma survivors at high risk following radiotherapy to breast tissue.
Are lymphoscintigrams needed prior to sentinel node biopsy using T99 isotope for localisation?
Breast Cancer patients’ perception of intra-operative radiotherapy (IORT): the South East England experience
Cambridge Early Phase Clinical Trials Team: Improving Access to Studies for Patients in the Anglian Region
Technological innovation in hereditary cancer risk assessment
The NCRI Future of Surgery initiative: Defining a research agenda for outcomes of surgical randomized controlled trials
Serious Adverse Events in Phase I oncology trials at The Christie NHS Foundation Trust
The development of an early warning system to improve the time from pathological diagnosis to initiation of systemic treatment in patients with extensive stage small cell lung carcinoma
Research Study: Continued Variation in Breast Cancer Follow Up Practice
Maligant bowel obstruction - How can we do better?
eRAPID electronic patient self-Reporting of Adverse-events- Patient Information and aDvice: Results from internal pilot phase of an RCT in systemic cancer treatment
Liverpool Healthy Lung Project : A proactive approach to finding undiagnosed early stage lung cancers.
A clinic for patients with suspected malignancy of undetermined origin (MUO)
Health-related quality of life in the screening and management of cervical disease: A systematic review
Improving the effectiveness of multidisciplinary team (MDT) meetings in NHS cancer services
The first half-decade of acute oncology: A single centre experience
Exploring the impact of multi-morbidities on costs of treating people with cancer
‘Trial exegesis’: Methods for synthesizing clinical and patient reported outcome (PRO) data in trials to inform clinical practice. A systematic review
Exploring the healthcare cost implications of cancer stage across the pathway
Health professionals’ views of current treatment pathways for cancer patients with comorbid diabetes.
Macmillan Physical Activity behaviour change care pathway - A formative evaluation
Improving Capture of Long-Term Follow-Up of Early Breast Cancer Survivors
Measuring the Quality of Personal Care in Patients Undergoing Radiotherapy for Prostate Cancer
New Combenefit software and mathematical models to quantify drug combinations synergy and antagonism
The Cks1/Cks2 Axis In Mll1-Dependent Wnt Signalling And Mixed Lineage Leukaemia.
MicroRNA-31 regulates chemosensitivity in malignant pleural mesothelioma via alterations in intracellular accumulation
Investigating the molecular mechanisms driving neuroendocrine differentiation in androgen deprived prostate cancer cells
Development of robust in vitro 3D models of human tumours for the identification and evaluation of anti-cancer drugs
Loss of PBRM1 rescues VHL dependent replication stress to promote renal carcinogenesis
Upregulated lncRNA-HNGA1, a target of miR-375, contributes to aerobic glycolysis of Head and Neck Squamous Cell Carcinoma through increasing levels of the glucose transporter protein SCL2A1
The prognostic potential of the long non-coding RNA MALAT1 in M0 prostate cancer
ADAM17: a potential regulator of resistance to EGFR targeted therapies in RAS wild type colorectal cancer.
RalB GTPase: a potential novel target for RASMT colorectal cancer
The role of Collagenase-3 in S100P and S100A4 overexpression metastatic breast cancer cells
A Possible Mechanism for Cells from Normal to Cancer?
Electrophysiology of autocrine and paracrine NMDA receptor signalling in invasive mouse pancreatic neuroendocrine tumour cells
Regulation of FLIP Long by the SCF(Skp2) ubiquitin ligase complex
Therapeutic compound discovery and validation of drugs targeting a recurrent glioblastoma (GBM) phenotype using LINCS compounds via QUADrATiC analyses
BCL3 and radiation sensitivity in rectal cancer
Assessment of EGFR Modulation in HPV negative Head and Neck Cancer Cells and The effect on Response to Targeted Therapies
Frizzled receptor 4 (FZD4) is associated with patient survival, invasiveness and tumour formation capacity in epithelial ovarian cancer
Downregulation of the citrullinating enzyme Peptidyl-arginine deiminase type-2 in ovarian cancer indicates poor prognosis
Genome-wide gene expression changes in KSRP silenced breast cancer cells
Development of a Novel Cellular Assay For Assessing Protein:Protein Interactions (PPIs) Between Extrinsic Apoptosis Proteins
Targeting NEDDylation in Colorectal Cancer
Ex-vivo prostate culture utilising ‘PEOPLE’ – PatiEnt prOstate samPLes for rEsearch
CRUK:Manchester Institute's Drug Discovery Unit's Focus on Success
Role of Protein Phosphatase 4 Regulatory Subunits in Myeloid Leukaemia
The dual mTORC1/2 inhibitor, AZD2014, potentiates the efficacy of palbociclib, a CDK4/6 inhibitor, in ER+ breast cancer.
Genomic patterns in low-grade prostate cancer indicative of upgrading
Combining the PI3Kβ/δ inhibitor, AZD8186, with the dual mTORC1/2 inhibitor, Vistusertib, gives increased anti-tumour effects in PTEN-deficient tumours.
Coffee consumption and risk of pancreatic cancer among non-smokers in the Million Women Study
Factors associated with recurrence and survival length following relapse in patients with neuroblastoma
Reducing Heart Toxicity In Medulloblastoma Using Proton Therapy
Lifetime BMI trajectory classes and obesity-related cancer risk in a US retrospective cohort study
UK Healthcare Professional Knowledge and Understanding of the Impact of Cancer Treatment Induced Oral Mucositis: A Delphi Consensus Study
Staff Awareness Of Oncology and Haematology Clinical Trials (OHCT) – Bridging The Information Gap