Poster session A


Room: Hall 2

Two-Year Efficacy and Safety Update: Phase III CheckMate 025 Study of Nivolumab vs Everolimus in Patients With Advanced Renal Cell Carcinoma (aRCC)
Weekly cisplatin concurrent with IMRT does not increase risk of Lhermitte's syndrome in head and neck cancer patients
The use of Oncotype Dx in adjuvant chemotherapy decision-making in early breast cancer patients with intermediate risk of mortality at 10 years
Gold nanoparticle radiopharmaceuticals for the selective treatment of telomerase-positive tumours
Fibroblast growth factor receptor 3 (FGFR3) mutant muscle invasive bladder cancers (MIBC) are associated with low immune infiltrates
The development of GBM - A single case study
Outcomes for patients diagnosed with metastatic pancreatic ductal adenocarcinoma (mPDAC): a tertiary referral centre experience.
European Cancer Incidence is Significantly Reduced in Huntington’s Disease Patients – Unravelling it’s Protective Mechanisms.
Statin use is associated with lower pro-tumourigenic (M2) macrophage number in the microenvironment of in situ versus invasive lung adenocarcinoma
Incorporating cancer risk information into general practice: a qualitative study using focus groups with healthcare professionals
Cervical cancer survival among women referred to cancer centres in Ghana
Investigation of the Role of Alcohol in Colorectal Tumour Development in Mouse Models
Understanding ethnic disparities in uptake of HPV vaccination in England: A comparative qualitative study
Is socio-economic status relevant in HPV oropharyngeal cancer?
Why do I choose to get screened? An examination of factors influencing participation in the Scottish Bowel Screening Programme
General practitioner attitudes towards prescribing aspirin to carriers of Lynch Syndrome: findings from a national survey
General Practitioner attitudes towards prescribing tamoxifen for the primary prevention of breast cancer: results of a vignette study
Views on provision of personalised cancer risk information: a qualitative interview study with members of the public
Routes to prostate cancer progression and identification of new drug targets: results from the CRUK-ICGC prostate initiative
The PrEvENT Feasibility Trial – Results of the Qualitative Feasibility Analysis
Bladder cancer risk is associated with low serum 25-hydroxyvitamin D levels; a systematic review
Prostate cancer meta-analysis from more than 143,000 men identifies 57 novel prostate cancer susceptibility loci
Forecasting the cancer population in the UK to 2040
Latest Feasibility Outcomes from the Prostate cancer Evaluation of Exercise and Nutrition Trial (PrEvENT)
Atezolizumab (atezo) in platinum (plat)-treated locally advanced/metastatic urothelial carcinoma (mUC): Updated OS, safety and biomarkers from the Ph II IMvigor210 study
IMvigor210: updated analyses of first-line (1L) atezolizumab (atezo) in cisplatin (cis)-ineligible locally advanced/metastatic urothelial carcinoma (mUC)
High-dose treatment with ADXS11-001, a Listeria monocytogenes-listeriolysin O (Lm-LLO) immunotherapy, in women with cervical cancer: a phase I, dose-escalation study
Targeting thioredoxin reductase in pancreatic cancer
Evaluation of biomarkers in the UK phase III VorteX trial confirms importance of tumour hypoxia in soft tissue sarcoma
Does pegfilgrastim reduce the incidence of neutropenic sepsis?
In the era of conservative surgery, can patients presenting with node positive breast cancer be spared axillary node dissection post neoadjuvant chemotherapy? A meta-analysis and review of literature
The role of sentinel lymph node biopsy in patients with ductal carcinoma in situ. An updated meta-analysis involving 9803 patients
Which patients with locally advanced pancreatic cancer should we be selecting for chemoradiotherapy?
Circulating cell-free DNA copy-number profiles as a biomarker in melanoma
Modelling the Emergence of Resistance to Chemotherapeutics with Virtual Tumour
Percentage change in mean corpuscular volume (MCV) and survival in patients with advanced renal cell carcinoma receiving sunitinib
A South Yorkshire audit to evaluate first line palliative treatment with Herceptin and doublet chemotherapy in patients with HER2 positive gastric or gastro-oesophageal cancer
Differential DNA methylation at the promoters of VEGF-B and VEGF-C is prognostic for clinical outcomes in ICON7 ovarian cancer patients and VEGF-C regulates cancer stem cell activity
When the breast surgeons take the lead in genetic testing, how satisfied are the patients?
Primary pulmonary pathology detected by screening for ovarian cancer using serial serum CA 125 assay in a risk of ovarian cancer (ROCA) based trial
Selection of PKH26HI quiescent populations selects for cells with insensitivity to TRAIL
Characteristics of older patients receiving cancer chemotherapy
A Retrospective Study of the use of Genomic Profiling in a Breast Cancer Screening Centre
Validation and comparison of a standardised ctDNA NGS assay across two laboratories
TMEPAI, A Novel Therapeutic Target in Triple Negative Breast Cancer Prevention and Therapy
Extralevator Abdomino-Perineal Resection Of The Rectum Should Not Be The Default Operation For Low Rectal Cancer
Clinical characteristics and treatment outcome of small cell cancer of the bladder; results from a 10-year experience from 3 UK cancer centres
A novel NGS based cancer genetic testing solution on high-throughput sequencer BGISEQ-500
CRUK SMP2: NGS of FFPE-extracted DNA from advanced NSCLC leading to selection of patients for The National Lung Matrix Trial
Use of implantable fiducial markers for IGRT in prostate cancer, North Wales experience
Differentiating tumour progression from pseudoprogression in patients with glioblastoma using multiparametric MRI imaging: data from Barts Health NHS trust London
Enzalutamide Effectiveness and Tolerability in Patients with Castration Resistant Prostate Cancer. Our Experience
Exploration of glioblastoma biology with liquid biopsy reveals a specific ctDNA fragmentation pattern.
Establishing a Platform Trial in the UK – early experiences of set-up and recruitment to the Add-Aspirin Trial
Prostate Cancer treated with External Beam Radiation therapy; Exploring Dose, Biomarkers and Quality of Life
Survivin, Endoglin and WT1 are frequently expressed in adult B-cell acute lymphocytic leukaemia
Audit assessing correlation between pre-operative MRI stage and histology findings post-laparoscopic radical prostatectomy.
Colorectal Cancer: Defining the immunological targets of reactive disease
Development of a hypoxia gene signature as a biomarker for treatment stratification in prostate cancer
A multicentre cohort study to redefine and validate pathological assessment of response to neoadjuvant therapy in treated oesophagogastric adenocarcinoma
A phase II study to determine the safety and efficacy of the dual mTORC inhibitor AZD2014 and to investigate additional toxicities in combination with rituximab in relapsed/refractory DLBCL
Carcinoma of Unknown Primary: prognosis with and without chemotherapy in Lancashire/South Cumbria in 2015
Metabolism, methylation and malignancy of the prostate
Immunological function in patients with different neutrophil to lymphocyte ratios in patients receiving chemotherapy for advanced colorectal cancer.
Disulfiram with or without metformin exhibits potent anti-cancer effects toward oesophageal squamous cell carcinoma in vivo.
Pharmacogenomics in children with cancer
Surgical management and oncological outcomes can be enhanced with selective use of post-chemoradiotherapy MRI in patients with high risk rectal tumours
Rectal cancer resection: Laparoscopic versus open surgery
Preoperative mapping and surgical technique for No Touch SMA first Pancreatico-duodenectomy: Initial experience
Poly lactic-co-glycolic acid controlled delivery of Disulfiram to target liver cancer stem-like cells
AMP-activated protein kinase expression in breast cancer in relation to obesity
20-Hydroxyeicosatetraenoic acid and its cytochrome-P450 isoform expression are linked to tumor proliferation in bladder cancer cells (RT4)
In vivo Skin dose measurements using TLD for head and neck patients treated with IMRT and 3D-CRT
Analysis of SWI/SNF Remodelling complex Catalytic Subunits mutations and Drug Sensitivity in Colorectal Carcinoma
Integrin signalling regulates YAP and TAZ to control skin homeostasis
Nucleoside-analogue tracing identifies a phenotypically distinct subpopulation of slow-cycling cells in high-grade serous ovarian cancer, providing an explaination for clinical relapse
Axl promotes metastasis of pancreatic cancer by regulating an EMT programm
Iterative Data Multiplexing Identifies Therapeutic Candidates for Oral Squamous Cell Carcinoma
Cancer microvesicles induce Tissue Factor-related procoagulant activity in endothelial cells in vitro.
NOTCH1 Mutations and Extracapsular Spread in Oral Squamous Cell Carcinoma Lymph Node Metastasis
miRNA inhibition as a potential tool to modulate drug response in cholangiocarcinoma (CCA)
Simultaneous analysis of tyrosine kinase receptors, HER2 and c-Met, by imaging flow cytometry in gastric cancer cells
Suppression of intratumour heterogeneity (ITH) by protein kinase C zeta (PRKCZ) control of centrosome (Csm) dynamics.
Cten stimulates cell motility through Src signaling in colorectal cancer.
Searching for synthetically lethal drug-virotherapy combinations.
Dual inhibition of the MEK5 and PI3K pathways synergistically reduces proliferation and viability in triple negative breast cancer cells
Structure of the cohesin loader Scc2-Scc4 and its binding to a folded cohesin
Functional analysis of RAD51B and RAD23B SNPs using Circular Chromosome Conformation Capture (4C) in human prostate cell lines
Targeting Post-Chemotherapy Breast Cancer Stem Cell Signalling
Organotypic slice ovarian cancer model as a platform to test novel therapeutics
Administration-specific migration of Th1 cells modulates the host immune system, tumor microenvironment, and antitumoral efficiency during immunotherapy in pancreatic cancer
Pathways of Cisplatin Resistance in Oesophageal Adenocarcinoma
The roles of PARP1 and SIRT1 in response to oxidative stress and implications for sex differences in cancer incidence
Role of iRhom2 in the pathogenesis of head and neck squamous cell carcinomas (HNSCC)
MicroRNAs as biomarkers of resistance to HER2 inhibitors in combination with chemotherapy in gastro-oesophageal cancer cell lines
5-Fluorouracil (5FU) intratumoural pharmacokinetics: rapid uptake in cells and spheroids.
Clonal interactions as mechanisms of polyclonality in colorectal adenomas
Interplay between MRTF and YAP in cancer-associated fibroblasts
The effect of Chk1 inhibitor MK-8776 on ADEPT in human colon cancer cell lines
The immune receptor Tim-3 is required for galectin-9 secretion in human acute myeloid leukaemia cells
Correlating Genetic Changes in NOTCH1 Expression with Changes in Cell Behaviour in Squamous Cell Carcinoma of the Head and Neck
Targeting an Achilles’ heel of cancer: Deubiquitylases as novel targets for centrosome de-clustering and cancer-cell specific cell death
Circulating tumour cells used to investigate tumour molecular status and heterogeneity in small cell lung cancer
Integrative Genomic Analysis of Mechanisms of a Novel Poor Prognosis Prostate Cancer Molecular Subtype
AXL Mediates Resistance to AKT inhibition in Oesophageal Adenocarcinoma.
Circulating Tumour Cell-Derived Explant Models from Small Cell Lung Cancer Patients
Myelodysplastic Syndrome can propagate from the Multipotent Progenitor compartment
Investigation of the role of N-glycosylation of CD24 in colorectal cancer
Cortisol alters the expression of DNMTs in Breast cancer cells
Circulating free DNA in colorectal cancer as a marker of surgical clearance
The role of aspartate metabolism in hypoxic breast cancer cells
Inducing HER2 endocytosis and downregulation via enhanced antibody-receptor clustering as a therapeutic strategy in breast cancer
Interaction between MUC1 and Galectin-3 promotes EGFR dimerization, activation and signalling in epithelial cancer cells
Overexpression of ABCB1 (MDR1) confers a common resistance mechanism to paclitaxel and selected PARP inhibitors in matched drug-sensitive and drug-resistant ovarian cancer cell lines
Organotypic cultures: a platform for assessing novel oncolytic therapy in solid tumours
ClearCell FX, a marker-independent process for enriching viable circulating tumour cells (CTCs) from melanoma patient blood
Optogenetic manipulation of tumour cell signalling
The Role of Vasculogenic Mimicry in Small Cell Lung Cancer
Circulating cell-free DNA analysis in limited and extensive stage small cell lung cancer
Identification of MCAM (CD146) as galectin-3 binding ligand responsible for galectin-3-mediated endothelial secretion of metastasis-promoting cytokines.
Molecular analysis of circulating free nucleic acids and CTC genomes in patients with pancreatic adenocarcinoma
The circulating galactoside-binding proteins endothelial secretion of cytokines in cancer
The prognostic significance of MET overexpression in head and neck squamous cell carcinomas
Defining transcription stress and the effect it has on genome stability
Shallow Whole Genome Sequencing can detect Copy Number Changes in FFPE material from Oesophageal Adenocarcinoma and Barrett’s Oesophagus
Use of a genome-wide haploid genetic screen to identify the critical mediators of response to novel combination therapy with gemcitabine and entinostat in pancreatic cancer: a proof-of-principle study
Automated scoring can be used to assess hypoxia marker expression in soft tissue sarcoma
Isolation of an epigenetically defined cisplatin tolerant proliferative population from a chemosensitive ovarian cancer cell line
Enhancement of apoptosis induction effect of docetaxel by suppressing FABP5 activity in prostate cancer cells
Genetic dependency profiling of synovial sarcoma cell lines
Changes to the nuclear periphery in disease states
A fingerprint of the metastatic niche
Increased vascular permeability contributes to disease progression and drug response in acute myeloid leukemia
A Module-based Regulatory Program Analysis Identifies Association Between EXO1 and MAP Kinase Inactivation in Triple Negative Breast Cancers
Outcomes and Prognostic Markers of Patients Admitted to Intensive Care: A Six-Year Analysis
The experience of blood cancer patients on a period of Watch and Wait
Creation of a peer Mentorship scheme in the POPS trial
Aspirin Utilization, Compliance and Prevention Of Colorectal Cancer – A Single Centre Perspective.
Mobilising public support to improve development of, access to and kinder drugs for children with cancer - a grass root NGO/Parent led movement
Pilot study on GPs’ preference about out patient consultation letters on breast cancer patients.
Reasons why patients accept or decline clinical trials within the gastrointestinal team
An Analysis Of Patient Participation In A Breast Radiotherapy Clinical Trial
Assessing patient preferences and perspectives of precision cancer medicine: A systematic review.
National regimen-specific consent forms for systemic anti-cancer therapy (SACT)
Cancer experiences in people with an intellectual disability: A PhD thesis
How can the EQUATOR Oncology Project help to improve the reporting of randomised controlled trials in oncology?
Weight gain in patients receiving adjuvant first line treatment for ovarian cancer
Managed local follow-up of long term lymphoma survivors – the ADAPT programme
Endoscopic management of gastrointestinal bleeding in cancer patients with severe thrombocytopenia
Outcome of Patients with Solid Tumours Admitted to Intensive Care
What is the evidence for holistic cancer rehabilitation programmes?
The impact of tyrosine kinase inhibitors on the treatment of gastrointestinal stromal tumours (GISTs): The Velindre Cancer Centre experience
Smoking After Cancer: A Qualitative Study Of The Challenges In Quitting Smoking After A Diagnosis Of, And Treatment For, Head And Neck Cancer
Quality of life outcomes in children and adolescents previously treated for medulloblastoma
Impact Of A CUP Service At The Royal Derby Hospital- One Year On
A retrospective evaluation of the current pathways of assessment and management of patients with neutropenic sepsis at the Northumbria Specialist Emergency Care Hospital
Diagnostic pathways for older people with suspected cancer: review of the Addenbrooke’s hospital rapid access geriatric assessment service (RADAR)
Cetuximab related hypersensitivity reactions – worthy of the hype?
The implementation of focused performance benchmarking as a method of regional quality improvement in breast cancer care.
Systemic Anti-Cancer Treatment for Solid Tumours: Why Door-To-Needle Time Is Important For Neutropenic Sepsis
Girls’ knowledge about HPV vaccine and cervical cancer
General Practitioners’ views on the provision of oral anti-cancer medicines
Breast One-stop Clinic: Concordance between Primary and Secondary Care
Multidisciplinary Meetings: should all patients be discussed?
How a collaboration between an Academic Maths Department and a local NHS Breast Cancer Service improve patient pathways.
Evolution of a Breast Cancer Trials Team
Development of drug-resistant colorectal cancer cell lines to investigate mechanisms of resistance and identify predictive biomarkers of drug response.
Mass-spectrometry profiling of extracellular matrix identifies citrulline as marker of colorectal cancer liver metastasis
Making Big Data available: Informatics Infrastructure supporting the MRC/CRUK funded Stratification in COloRecTal Cancer (S-CORT) programme
First impressions count: Initial clinical and radiological features independently predict for overall survival in older patients with Glioblastoma
Dose escalation of axitinib on disease progression as a strategy in the treatment of metastatic renal cell carcinoma
Treatment with neoadjuvant BRAF/MEK inhibitors yields high response rates in patients with high-risk resectable melanoma
Chk1 inhibition activates replication stress and catastrophe in an unperturbed S-phase
Fingerprinting Heterogeneity of Glioma using PET-MR Information
MicroRNA regulation of DNA damage response to radiotherapy
Co-delivery of Doxorubicin and Radionuclide therapy using EGF-tagged drug carriers for the treatment of EGFR-positive cancer cells
Role of miR-9 and its target CXCR4 in head and neck cancers
Targeting KRAS dependent tumors with AZD4785, a high-affinity therapeutic antisense oligonucleotide inhibitor of KRAS
AR targeted therapy in ovarian cancer: first results with abiraterone in the phase II Cancer of the Ovary Abiraterone (CORAL) Trial (CRUKE/12/052)
A retrospective study of the toxicities of immunotherapies used in the treatment of disseminated malignant melanoma and an audit of their management
Liquid Biopsy in Metastatic Prostate Cancer
Programmed death-ligand 1 (PDL-1) and immune infiltrates are prognostic for better outcome and enriched in the ATM (ataxia telangiectasia mutated)-low segment of gastric cancer (GC)
Accelerative integromics: dynamic biomarker discovery using big data.
Delineating the role of chromosome 6 aberrations associated with the prognosis of primary uveal melanoma.
Identification of Texture Features from FDG PET images that are associated with Survival Outcomes in Non-small Cell Lung Cancer
Hypofractionated dose painting IMRT for intermediate to high risk localised prostate cancer: boosting to 68 Gy in 20 fractions
A systematic review and meta-analysis on the role of music in reducing anxiety and discomfort during flexible sigmoidoscopy
The impact of ApE1 gene polymorphism on endometrial cancer in Iranian population
Expression of Soluble c-Met in the serum and peritoneal fluid of the patients with different stages of Endometrial Cancer
Soluble CD44 in the serum and peritoneal fluid of the patients with Endometrial Cancer
HER2 testing in gastric adenocarcinoma
Biomarker based identification of aggressive prostate cancer in blood and urine samples
30-day mortality after systemic anti-cancer treatment for breast and lung cancer in England - which factors affect the risk? - the first national population based study
Acceleration of Gene Expression Connectivity Mapping using GPUs within the QUADraTic System
Can we use N-acetyl-L-aspartyl-L-glutamate peptidase-like 2 to target drugs to cancer cells?
Profiling circulating microRNAs in early screen detected breast cancer
Assessing mechanisms of tumour evolution using alignment-free methods
A novel cell surface pancreatic and cholangiocarcinoma biomarker that promotes resistance to Gemcitabine
Using mp-MRI guided prostate needle biopsy samples to improve prostate cancer diagnosis.
Evolution of gastro-oesophageal cancers and selection of therapy resistant subclones through metastatic dissemination
Novel diagnostic and prognostic prostate cancer biomarkers buffer the translational burden of neoplastic transformation
INNOVATE: A prospective cohort study combining serum and urinary biomarkers with novel diffusion-weighted MR imaging for the prediction and characterisation of prostate cancer.
Expression of PD-L1 in non-small cell lung cancer: a series of 1,107 cases
EGFR mutation testing on cell free circulating tumour DNA: the Birmingham Molecular Pathology Diagnostic Service
The molecular epidemiology of KRAS and NRAS mutations in 2,761 colorectal adenocarcinomas
Performance review of TEMS(Transanal Endoscopic MicroSurgery)/TAMIS(TransAnal Minimally Invasive Surgery) for excision of rectal lesions in a District General Hospital
Changing referral patterns and colorectal cancer (CRC) detection rates over 10 years in a UK specialist centre.
Exploring Clinical Decision Making in the Treatment of Cancer in Older Patients
Optimising oncology outcomes with a mobile app for breast cancer patients: A qualitative evaluation
Audit of BRCA1 and BRCA2 gene mutation detection rate in women with triple negative breast cancer diagnosed under 60 years
Defining patient-centred real-life clinical pathways during chemotherapy
Where next for cancer services in Northern Ireland, Scotland and Wales? An evaluation of priorities to improve patient care
Defining the Surgical Contribution to Cancer Research in the UK
Serious Illness Care Programme UK: Assessing the ‘face validity’ and acceptability of the Serious Illness Conversation Guide (SICG) for use within the UK health care setting.
Tolerability and efficacy of Rolapitant for prevention of Chemotherapy induced nausea and vomiting: A systematic review and meta-analysis of active-controlled trials.
Research Opportunities for Teenage and Young Adult Cancer Patients
Frequency and nature of presenting abdominal symptoms in cancer patients before diagnosis: evidence to inform the design and evaluation of generic symptom awareness campaigns
Typical and atypical symptoms in women with breast cancer: Evidence of variation in diagnostic intervals from a national audit of cancer diagnosis
A multicentre survey of teenage and young adult cancer patients: fatigue is prevalent, poorly managed and perpetuates long term
COAST (Cisplatin Ototoxicity Attenuated by Aspirin Trial): A phase II double blind, randomised controlled trial to establish if aspirin reduces cisplatin induced hearing loss
Enterosorption as a supportive treatment during external radiotherapy in patients with uterine and cervical cancer
Outcome of patients with solid malignancies and suspected Pneumocystis jiroveci pneumonia (PJP)
Quantifying long-term morbidity following cervical cancer treatment: A retrospective comparison of the Royal College of Radiologist’s (RCR) Morbidity Audit and routine population-based cancer datasets
A Dietary and Physical Activity Interventions for Colorectal Cancer Survivors: A Randomized Controlled Trial
The current evidence base for the feasibility of 48-hour Continuous Subcutaneous Infusions (CSCIs): a systematically-structured review.
Follow up after cancer treatment: Improving access to supported self-management through testing of a GP led Active Inclusion Pathway
Decision-making of Treatment in Advanced Lung Cancer; the PACT Study: An Intervention to Support Advanced Lung Cancer Patients and Their Clinicians When Considering Systemic Anti-Cancer Therapy